Why is NSC the Preferred Form and Brand of Beta Glucan?
The process of extraction, including particle size reduction and protection to prevent reaggregation in NSC MG Beta 1,3/1,6 glucan, has a direct bearing on the degree of immune potentiation of any particular Beta Glucan product, with immuno-potentiation abilities ranging from negligible to extremely high, with NSC MG Beta 1,3/1,6 glucan in the extremely high category.
The microparticulate size of 1-4 microns in NSC MG Beta 1,3/1,6 Glucan, versus larger globular or reaggregated particulate glucan in most competitor products, is indicated by research to be more potent in immune response potentiation as evidenced by the increased nitric oxide burst in the macrophage cells.
The nitric oxide burst is a killing mechanism for microbes, including bacteria, viruses and fungi, for the large white immune cell immune cell designated as a macrophage.
Particle size importance is proven conclusively by at the University of Nevada School of Medicine, Department of Microbiology in an extensive research project spanning two decades. Further evidence is provided under the heading “micronization” for beta 1,3/1,6 glucan at www.betaglucan.org.
However, more than small particle size on ingestion is required, because orally taken Beta Glucan reaggregates, or clumps back, into a larger size when exposed to water in the digestive process. This reaggregation effectively returns even reduced sized particles at time of intake back to a larger particle sizes due to clumping together in the digestive process.
Unless processed to create non-aggregation, the globular/reaggregated glucan particles then arrive in globular sizes in the Peyers’ Patch of the lymphatic system to attempt to activate receptor sites dectin 1 or CR3 on the macrophage or other immune cells that are 1 to 4 microns in size. The large particle size is thus less effective in activation and has reduced immune potentiation capabilities.
Insoluble particulate Beta Glucan taken orally, in contrast to water soluble for injection, is marketed as a dietary food additive supplement that nutritionally empowers the immune system to normalize. Normalization refers to maintaining if functioning properly; building up if substandard and calming down if hyper. An immune system representing 20% of the body’s cells in peak condition provides the most protective disease defenses, faster recoveries, enhanced shielding from radiation damage plus environmental hazards and an extension of life associated with good health. We all seek a quality, not just quantity of life and the immune system is a major key!